At its core, this innovation fundamentally distinguishes itself from previous approaches in neuromorphic computing. Unlike digital processors or earlier neuromorphic chips that relied on mathematical models to merely simulate brain activity, these novel artificial neurons physically replicate the fundamental operational principles of real neurons. This means they don’t just abstractly represent brain functions; they tangibly recreate them. Just as the complex symphony of natural brain activity is initiated and propagated by electrochemical signals, these artificial counterparts harness actual chemical interactions to trigger and execute computational processes. This tangible recreation of biological function marks a paradigm shift, moving beyond symbolic representations to a more authentic emulation of neural dynamics.
This pioneering research, spearheaded by Professor Joshua Yang of USC’s Department of Computer and Electrical Engineering, builds upon his foundational work in artificial synapses, a field he began exploring more than a decade ago. The team’s latest breakthrough centers on a novel device they’ve termed a "diffusive memristor." Their groundbreaking findings elucidate how these sophisticated components can pave the way for an entirely new generation of computing chips, designed not only to complement but to significantly enhance existing silicon-based electronics. While traditional silicon systems fundamentally rely on the flow of electrons to perform computations, Yang’s diffusive memristors ingeniously employ the motion of atoms to achieve similar, and in some respects, superior results. This atomic-level manipulation more closely mirrors the way biological neurons transmit information, leading to the potential for smaller, more energy-efficient chips that process information with the same elegance and efficacy as the human brain, ultimately bringing AGI within closer reach.
The intricate dance of communication between nerve cells in the brain is orchestrated by a dynamic interplay of both electrical and chemical signals. When an electrical impulse traverses a neuron and reaches its terminal, a specialized junction known as a synapse, it undergoes a crucial transformation. Here, the electrical signal is converted into a chemical signal, which then traverses the synaptic gap to transmit information to the next neuron in the network. Upon reception by the subsequent neuron, this chemical signal is reconverted back into an electrical impulse, enabling the information to propagate further through the neural pathway. Yang and his team have achieved a remarkable feat by replicating this complex, multi-stage process with astonishing accuracy within their artificial devices. A key advantage of their design lies in its exceptional miniaturization; each artificial neuron can be fabricated within the physical footprint of a single transistor. This is a dramatic improvement over earlier designs, which often required tens or even hundreds of transistors to achieve comparable functionality.
In the biological realm, charged particles known as ions are indispensable for generating the electrical impulses that fuel activity within the nervous system. The human brain, a marvel of biological engineering, relies on a specific cocktail of ions, including potassium, sodium, and calcium, to facilitate these vital electrochemical processes. Understanding this fundamental biological mechanism was crucial for the USC team’s endeavor.
The heart of this transformative research lies in the ingenious utilization of silver ions to meticulously recreate the complex dynamics observed in natural brain function. Professor Yang, who also leads the USC Center of Excellence on Neuromorphic Computing, employed silver ions, carefully embedded within carefully selected oxide materials, to generate electrical pulses that precisely mimic the fundamental processes underpinning human cognition. These processes include essential functions such as learning, the execution of movement, and the complex cognitive act of planning.
"Even though it’s not exactly the same ions in our artificial synapses and neurons, the physics governing the ion motion and the dynamics are very similar," Professor Yang explained, highlighting the fundamental similarities in the underlying physical principles. This similarity is key to achieving functional emulation.
Yang further elaborated on the strategic choice of silver: "Silver is easy to diffuse and gives us the dynamics we need to emulate the biosystem so that we can achieve the function of the neurons, with a very simple structure." The novel device responsible for enabling these brain-like chips has been christened the "diffusive memristor," a name derived from the crucial role of ion motion and the dynamic diffusion that occurs when utilizing silver.
The rationale behind embracing ion dynamics for the construction of artificial intelligent systems is deeply rooted in biology. "The team chose to utilize ion dynamics for building artificial intelligent systems ‘because that is what happens in the human brain, for a good reason and since the human brain, is the ‘winner in evolution-the most efficient intelligent engine,’" Yang stated, emphasizing the evolutionary advantage of biological design.
"It’s more efficient," Yang reiterated, underscoring a critical advantage of this approach.
The emphasis on efficiency is paramount in the context of artificial intelligence hardware. Yang pointed out a significant limitation of current computing paradigms: "Yang emphasizes that the issue with modern computing isn’t lack of power but inefficiency. ‘It’s not that our chips or computers are not powerful enough for whatever they are doing. It’s that they aren’t efficient enough. They use too much energy,’ he explains." This inefficiency is particularly problematic given the colossal energy demands of today’s large-scale AI systems, which require immense computational resources to process vast datasets.
Yang went on to articulate a fundamental difference between biological and artificial systems: "Yang goes on to explain that unlike the brain, ‘Our existing computing systems were never intended to process massive amounts of data or to learn from just a few examples on their own. One way to boost both energy and learning efficiency is to build artificial systems that operate according to principles observed in the brain.’" This highlights a design philosophy that prioritizes emulating nature’s most successful computing architecture.
While electrons, the workhorses of modern computing, excel at rapid operations, Yang explained that their suitability for emulating brain principles is limited. "If you are looking for pure speed, electrons that run modern computing would be the best for fast operations. But, he explains, ‘Ions are a better medium than electrons for embodying principles of the brain. Because electrons are lightweight and volatile, computing with them enables software-based learning rather than hardware-based learning, which is fundamentally different from how the brain operates.’" This distinction between software-based and hardware-based learning is a critical divergence from biological intelligence.
In stark contrast, Yang noted, "The brain learns by moving ions across membranes, achieving energy-efficient and adaptive learning directly in hardware, or more precisely, in what people may call ‘wetware.’" This concept of "wetware" encapsulates the idea of biological computation occurring at a fundamental, physical level, rather than through abstract software instructions.
To illustrate the profound efficiency of biological learning, Yang provided a compelling example: "For example, a young child can learn to recognize handwritten digits after seeing only a few examples of each, whereas a computer typically needs thousands to achieve the same task. Yet, the human brain accomplishes this remarkable learning while consuming only about 20 watts of power, compared to the megawatts required by today’s supercomputers." This stark contrast underscores the potential for significant energy savings through bio-inspired computing.
Looking ahead, Yang and his team view this pioneering technology as a crucial stepping stone towards achieving a faithful replication of natural intelligence. However, they acknowledge a present challenge: the silver utilized in their current experiments is not yet compatible with the established semiconductor manufacturing processes. Future research will therefore focus on exploring alternative ionic materials that can achieve similar remarkable effects, paving the way for broader industrial adoption.
The diffusive memristors developed by the USC team are exceptionally efficient in both energy consumption and physical size. To put this into perspective, a typical smartphone today houses approximately ten chips, each containing billions of transistors that tirelessly switch on and off to execute computations.
"Instead [with this innovation], we just use a footprint of one transistor for each neuron. We are designing the building blocks that eventually led us to reduce the chip size by orders of magnitude, reduce the energy consumption by orders of magnitude, so it can be sustainable to perform AI in the future, with similar level of intelligence without burning energy that we cannot sustain," Professor Yang stated, outlining the ambitious vision for future AI hardware.
With the successful demonstration of these capable and remarkably compact building blocks – artificial synapses and neurons – the next critical phase involves integrating a vast number of these components. The team aims to test how closely they can replicate the brain’s unparalleled efficiency and sophisticated capabilities. "Even more exciting," Yang concluded, "is the prospect that such brain-faithful systems could help us uncover new insights into how the brain itself works." This opens up a dual pathway of technological advancement and fundamental scientific discovery, promising a future where artificial intelligence not only mimics but also deepens our understanding of the most complex system known: the human brain.

